Intraarticular injection of hyaluronan as treatment for knee osteoarthritis: What is the evidence?
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چکیده
منابع مشابه
Intraarticular corticosteroid for treatment of osteoarthritis of the knee.
BACKGROUND Osteoarthritis (OA) is a common joint disorder. In the knee, injections of corticosteroids into the joint (intra-articular (IA)) may relieve inflammation, and reduce pain and disability. OBJECTIVES To evaluate the efficacy and safety of IA corticosteroids in treatment of OA of the knee. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issu...
متن کامل(Orthovisc) in osteoarthritis of the knee: a randomized, controlled, multicenter Clinical effects of intraarticular injection of high molecular weight hyaluronan
Objective. To evaluate the efficacy and safety of injection of high molecular weight (HMW) hyaluronan (Orthovisc®) in patients with mild, moderate, and severe knee osteoarthritis (OA). Methods. A randomized, arthrocentesis-controlled, multicenter trial. Patients (n = 372) were randomized to 4 weekly HMW hyaluronan injections (O4, n = 128), 3 weekly HMW hyaluronan injections followed by one arth...
متن کاملIntraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis
INTRODUCTION Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes (measured by stride times) in a murine model of OA. METHODS OA was induced in the right k...
متن کاملLongterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.
OBJECTIVE Intraarticular (IA) hylan injections constitute second-line therapy for osteoarthritis (OA) of the knee, but human studies suggesting a possible mechanism of action are lacking. We examined the effect of IA Hylan GF-20 injections on synovial fluid (SF) hyaluronan (HA) concentration, viscosity, and elasticity over a 6-month period in patients with mild to moderate OA of the knees. ME...
متن کاملIntraarticular cortisone injection for osteoarthritis of the hip. Is it effective? Is it safe?
Osteoarthritis of the hip is a significant source of morbidity in the elderly. Treatment guidelines are available for the management of hip osteoarthritis, but these do not address the application of intraarticular corticosteroid injection. The intraarticular injection of corticosteroid is used in the management of other large joint osteoarthritic diseases and is well studied in the knee, howev...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2000
ISSN: 0004-3591,1529-0131
DOI: 10.1002/1529-0131(200006)43:6<1192::aid-anr2>3.0.co;2-l